Despite the growing number of therapeutic options available for the treatment of retinal vascular diseases, current therapies for these conditions are not always effective. Subthreshold laser, used either as monotherapy or in combination with other treatment options, may provide a safe way of targeting pathologic retinal lesions without damaging healthy tissue. Our preliminary experience thus far looks promising, especially when using this form of laser therapy as an adjuvant in pharmacotherapy-resistant patients. However, further studies with additional patients and longer follow-up are needed to determine optimal laser parameters and to demonstrate safety and efficacy in different retinal diseases. To that end, we are currently planning prospective studies to validate our initial positive experiences.