Conclusions: “The YSML has progressively been recognized as an effective treatment option for several chorioretinal diseases. A growing body of evidence highlights its efficacy and safety in both short- and long-term follow-ups. Based on the literature, YSML can be considered a safe, cost-effective and non-invasive therapeutic procedure. It is less destructive with fewer potential adverse effects like CNV, RPE atrophy or choroidal ischemia compared to CW laser. Nevertheless, a more accurate standardization of laser setting protocols is still desired, and a better understanding of the underlying molecular mechanisms would be pivotal for the future advancement and optimization of this relatively new treatment approach. Further randomized prospective studies with longer follow-up and larger sample size studies are warranted to confirm its role in chorioretinal diseases management.”