“We conclude a less-intensive, individualized retinal photocoagulation, targeting only retinal quadrants with retinal neovascularization, has a similar efficacy as standard PRP in patients who are regularly seen in the clinics. In addition, limited side effects, balanced between groups, could indicate a gentler approach performed by the navigated laser system used in both treatment arms. This pilot study adds to the ongoing discussion of individualizing and balancing efficacy and side effects in PDR. Although VA loss was prevented at month 6 in our study, we cannot speculate to the long-term sustainability of results. Thus, upcoming randomized trials addressing long-term VA and treatment efficacy, and including additional relevant end points such as electroretinography would be important to confirm these findings.”