Conclusion: “There is a broad spectrum of types of DME, each of which demands a different mode of treatment, whether it is with anti-VEGF therapies, photocoagulation, or a combination of both. As physicians, our overall goals are to treat DME, to maintain our patients’ vision successfully, and to reduce the burden on our patients. In our hands, the OCT-based navigated laser approach has helped to improve outcomes and decrease treatment burden. Overall, it has enabled us to improve the accuracy and reproducibility of laser treatments, and it appears also to have improved retinal thickness outcomes to the level of anti-VEGF therapies (although further study is warranted). Perhaps most importantly, the navigated laser approach allows us to target microaneurysms precisely and effectively, while compensating for inadvertent eye movements and increases the likelihood that we will deliver the full laser treatment indicated for each patient. As with other technological advancements, navigated laser helps us standardize DME treatment, building on what had previously been more of an art, allowing more of us to deliver the results we aspire to achieve for our patients.”