Summary: “Employing navigated laser in the treatment of retinal disease provides numerous advantages over conventional slit-lamp laser coagulation, including fast application of laser spots through prepositioning, precise, confluent and complete coverage of desired treatment areas, and integration of all imaging modalities to allow for the creation of a complete digital treatment plan. Our study, the first-ever comparison of three different navigated laser treatment parameters, indicates that all laser modalities could safely and easily be applied in a standard clinical setting.”