“In the future, novel treatments such as gene therapy or anti-inflammatory drugs might be poised to play a crucial role in the management of DME. Nevertheless, recent advancements in laser technology and multimodal imaging have demonstrated new potential applications for laser photocoagulation, even in the era of widespread use of anti-VEGF drugs and steroids. These innovative techniques aim to optimize treatment outcomes while minimizing adverse events and alleviating the burden of frequent injections, thereby offering significant value to DME management. These developments instill hope for patients with DME and underscore the importance of ongoing research in the field of laser photocoagulation.”